Corium’s MicroCor® system utilizes dissolving microstructures (microneedles) for the safe, effective and convenient transdermal delivery of biologics.
This technology can also be combined with small molecules, when rapid onset of action is desired.Our lead product, MicroCor PTH(1-34) for the treatment of osteoporosis, has successfully completed Phase 2a clinical evaluation. We have also demonstrated the ability to incorporate a wide range of molecules into the MicroCor system, from small molecules to peptides, proteins, monoclonal antibodies and vaccines.
In MicroCor drug-in-tip technology we blend active therapeutic agents with proprietary polymer and excipient combinations to create arrays of solid-state biodegradable microstructures. These arrays are designed specifically to optimize the delivery of therapeutic or prophylactic agents either locally or systemically. MicroCor arrays penetrate the superficial layers of the skin, dissolving or biodegrading upon application. This eliminates the bleeding and discomfort associated with traditional injections.
Additional benefits include:
- Simple, one-step administration
- Short (<5 minutes) wear time
- No needles or sharps, providing a safer delivery system for healthcare workers and caregivers
- No need for refrigeration, simplifying handling and storage, and reducing spoilage; and
- Ability to customize the pharmacokinetic profile, allowing for immediate or sustained release.
Moreover, by delivering vaccines to the upper layers of the skin, which are rich in antigen-presenting cells, we have demonstrated a more robust and consistent immune response, with potential for dose sparing and, in some cases, the avoidance of adjuvants.
Corium has established GMP manufacturing facilities, quality systems for scale-up, and cost-effective manufacturing processes to support early-stage through clinical development programs.
Microstructures Enable Transdermal Delivery of Any Size Molecule
Microstructures are comprised of 2 layers; a dissolving drug-in-tip layer (in orange) and a water insoluble backing layer (in blue).
Upon application to the skin, the microstructures, which are few hundred μm in length, penetrate into the outer layers of the skin. The moisture in the skin rapidly hydrates the drug-in-tip layer.
Within 5 minutes, the drug-in-tip layer is dissolved and the active agent rapidly diffuses into blood vessels in the dermal layer. The water insoluble backing layer is removed.